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OKT3 T細(xì)胞活化抗人CD3單克隆抗體
閱讀：4166發(fā)布時(shí)間：2017-11-16
T細(xì)胞活化抗人CD3單克隆抗體（Functional，clone: OKT3）可以與TCR復(fù)合物結(jié)合，激活T細(xì)胞。SAFIRE(Sodium Azide Free Immensely Reduced Endotoxins) 類產(chǎn)品是BioGems品牌下的功能性抗體產(chǎn)品。
T細(xì)胞活化抗人CD3單克隆抗體的克隆號(hào)是OKT3。OKT3單克隆抗體特異性結(jié)合T細(xì)胞的CD3/TCR 復(fù)合物（T lymphocyte antigen receptor，T細(xì)胞抗原受體）的ε 鏈。CD3復(fù)合物包含γ, δ, and ε三條鏈，是TCR復(fù)合物的一部分，所有成熟T細(xì)胞都會(huì)表達(dá)。CD3可以增強(qiáng)信號(hào)轉(zhuǎn)導(dǎo)的抗原識(shí)別。
T細(xì)胞活化抗人CD3單克隆抗體訂購信息
品牌 | 產(chǎn)品名稱 | 貨號(hào) | 規(guī)格 | 單價(jià) | * |
PeproTech/BioGems | Anti-Human CD3 SAFIRE Purified | 05121-25-500 | 500 μg | ￥4,130 | ￥1,652 |
PeproTech/BioGems | Anti-Human CD3 SAFIRE Purified | 05121-25-100 | 100 μg | ￥2,240 |
|
PeproTech/BioGems | Anti-Human CD28 SAFIRE Purified | 10311-25-500 | 500 μg | ￥3,640 | ￥1,456 |
PeproTech/BioGems | Anti-Human CD28 SAFIRE Purified | 10311-25-100 | 100 μg | ￥1,820 |
|
T細(xì)胞活化抗人CD3單克隆抗體產(chǎn)品保存和質(zhì)控
產(chǎn)品原液保存在4°C。不能冷凍。單克隆抗體經(jīng)過親和層析純化。內(nèi)毒素水平：蛋白質(zhì)小于0.01 EU/µg，鱟試劑檢測(cè)法。
T細(xì)胞活化抗人CD3單克隆抗體英文版說明
The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.
Preperation: The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation: Phosphate-buffered aqueous solution, ph7.2.
References: Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.
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